GLP-1s and Women's Health: PCOS, & the Ashley Koff Protocol

Navigating the challenges of polycystic ovary syndrome (PCOS) requires not only an understanding of its complex symptoms but also an appreciation for the latest advancements in treatment. Excitingly, glucagon-like peptide-1 (GLP-1) receptor agonists, traditionally used in diabetes care, are now making a significant impact on the hormonal health of women with PCOS, especially those experiencing insulin resistance.

Exploring the Role of GLP-1 in PCOS 💉

GLP-1 receptor agonists work by enhancing insulin secretion, curbing glucagon production, and slowing gastric emptying. These actions collectively boost insulin sensitivity and promote weight loss, which are particularly beneficial for managing PCOS. This is because insulin resistance and elevated insulin levels often amplify the hormonal disturbances seen in this condition.

The Benefits of GLP-1 Therapy for Hormonal Balance ⚖️

Through GLP-1 therapy, many women with PCOS experience a transformative change in their hormonal profiles. By enhancing insulin sensitivity, these treatments help reduce the hyperinsulinemia that often triggers the ovaries to produce excessive androgens. The resulting decrease in androgen levels can lead to noticeable improvements in symptoms such as hirsutism, acne, and irregular ovulatory cycles.

Monitoring Blood Glucose in PCOS: A Key Step 🩸

Effectively managing PCOS starts with recognizing the specific type of the syndrome. Monitoring blood glucose is crucial, particularly in cases of insulin-resistant PCOS, to assess the extent of insulin issues. This allows treatments to be finely tuned to each individual's metabolic needs, ensuring more targeted and successful outcomes.

How are you tracking blood sugar with patients? At flöka, we connect to most CGMs like Dexcom or enable a patient to report blood-price test values. We are excited announce our latest integration, Freestyle Libre!

Revolutionizing PCOS Treatment with GLP-1

The introduction of GLP-1 receptor agonists has significantly shifted how PCOS is managed, especially in patients with associated obesity and insulin resistance. These medications do more than just control blood sugar; they play a vital role in balancing hormones, offering a comprehensive approach to tackle the intricate factors involved in PCOS.

Integrating Holistic Lifestyle Changes for Sustainable Health 🧘🏽‍♀️

While GLP-1 receptor agonists are powerful, their full potential is best realized when combined with holistic lifestyle modifications. That’s where you come in! Encouraging patients to integrate a balanced diet, regular physical activity, and effective stress management into their routines can greatly enhance the effects of medication. Protein to build lean muscle mass is also key. As allied and integrative providers, it’s essential to support patients in adopting these lifestyle changes to ensure both immediate benefits and long-term health improvements. To change habits takes time and accountability, and that is where you can truly partner with patients to make changes that last a lifetime.

A Bright Future in PCOS Treatment 😎

GLP-1 receptor agonists are at the cutting edge of new treatments for PCOS, providing renewed hope for those affected by this challenging syndrome. By enhancing insulin sensitivity and modulating hormonal imbalances, these treatments offer a holistic approach to improving symptoms and quality of life. With ongoing research and clinical developments, the role of GLP-1 in PCOS management is poised to become even more personalized and effective.


Happy learning to all those as the Fullscript Cardiometabolic Summit today! Recently at IHS in NYC, we heard a fabulous talk where Ashley Koff RD and Dr. Shah discussed how they implement GLP-1 alongside their nutrition programs. We got to meet Ashley Koff IRL (finally), and her team has generously offered to share a huge goodie for our community:

Every patient will benefit from optimizing their own GLP-1 production as part of blood sugar, appetite, digestive and immune health efforts - whether taking a GLP-1 agonist or not. We are thrilled to share an opportunity to SAVE $200 using code FLOKA200 on The Better Nutrition Program’s GLP-1 Practitioner Protocol Package that includes Ashley Koff RDs research- based protocol, a customizable nutrition plan, a resource guide for patients and a webinar recording.

What is BNP? 👇

The Better Nutrition Program was founded by award-winning personalized nutrition practitioner, speaker, author, educator and consultant, Ashley Koff RD to transform lives through personalized nutrition.  

For over two decades, Koff has been a guiding force in promoting and maintaining better health through a truly personalized approach. Throughout her experience, she has developed innovative tools, including experiments and in-depth evaluations, that complement traditional assessments such as labs, biometrics, interviews, and now wearables. This comprehensive approach aims to precisely identify each individual's specific needs while discovering what will make those choices doable, more often.

Alongside her she leads a diverse team of expert clinicians and board-certified health coaches to help empower individuals to make sustainable, practical choices personalized to their specific needs, all encapsulated within BNP's "better not perfect" System™. As a trusted resource for practitioners, businesses, media, and education, Ashley Koff RD and BNP are leading the charge in transforming lives through personalized nutrition.

Until next time, Happy Innovating!

- your flöka team